3月15日13時に第15期公募情報を公開いたしました。
4月1日13時より応募者登録サイトへの登録が可能です。
Information on the 15th call for applications was opened at 13:00 on 15 March.
Applicants can register on the registration website from 1 April at 13:00.
『 Reverse Bioengineering for precision medicine 』
One of the ultimate goals of bioengineering is to re-create natural living systems by means of synthetic biology and tissue engineering. The long-termmission of our laboratory is to recapitulate the in vivo human physiology and pathology on a microfluidic device, such as “Body-on-a-Chip” (BoC). Indeed,due to their capacity to recapitulate in vivo physiological and pathological conditions, BoC exhibit great potential as alternatives for pre-clinical animal tests to assess drug efficacy and safety. Although several chips and systems have been reported in the last decade, there are still some important issues that need to be addressed; these include: 1) the use of functional tissue cells derived from human pluripotent stem cell (hPSC), 2) the alternatives of polydimethylsiloxane (PDMS) to prevent chemical absorption, and 3) the integration of in situ monitoring systems to monitor cellular responses. Here, I will introduce our interdisciplinary approach of stem cell biology, material science, and micro/nano-engineering to address the aforementioned issues involved in drug discovery and precision medicine.