The Hakubi Project

The human body, consisting of multiple cells, is maintained through continuous cell proliferation and loss, while cells inevitably acquire mutations in their genome during cell division. Somatic mutations can give arise amino acid changes in protein, which could be resulted in changes in cell function. The environment surrounding cells selects cells with more fitness than those without, and the body continues to be remodeled by such cells. In this lecture, I would like to introduce our research to elucidate the pathogenesis of chronic diseases by analyzing genomic and epigenomic aberrations accumulated in cells in organs with disorders.