No.97 Seminar ： Oxygen-deficiency; Good or Bad for Cancer Therapy?
- Hiroshi Harada (The Hakubi Center for Advanced Research, Institute for Research in Humanities)
- 2015/07/07 4:30pm
- The Hakubi Center for Advanced Research (iCeMS West Wing 2F, Seminar Room)
- Japanese
Summary
Growth of malignant tumor depends on oxygen and nutrients supply from tumor blood vessels, which supports an idea of the so-called “Starvation Tactics” using an vascular-disrupting or anti-angiogenic agent. However, accumulating evidence has demonstrated that resultant hypoxic microenvironments in a tumor tissue unexpectedly induce malignant phenotypes of cancer cells. In the seminar I would like to talk about molecular mechanism underlying the hypoxia-mediated promotion of distant metastasis and chemo-/radio-resistance of cancers and introduce potential strategies to overcome these difficulties.