No.278 Seminar ： Deciphering the molecular mechanisms regulating cell mechanics
- Associate Professor Akifumi Shiomi, 15th batch, Institute for Life and Medical Sciences
- 2025/11/18 4:45pm
- Research Administration Building, Basement Floor (Conference Rooms 1&2)
- Talk in Japanese, with slides in English
- Onsite and Zoom
Summary
Mechanical properties of cells are coupled with the physiological states in various biological contexts such as cell differentiation, cancer, and aging. However, the molecular cascade underlying the transition in the mechanical properties largely remains to be uncovered because of the limited tools to interrogate the link between the mechanical properties and the molecular regulation. In this seminar, I will introduce my previous work on the unique mechanism by which Drosophila cells acquire extreme deformability, and present our recently developed method, ELASTomics, which enables simultaneous measurement of mechanical phenotyping and transcriptome. I will also discuss part of the research I am conducting under the Hakubi Project.