No.238 Seminar ： Development of a method to call directly to the monkey brain and elucidation of the neural mechanism of auditory hallucinations in schizophrenia
- Naho Konoike, associate professor at the Center for the Evolutional Origin of Human Behavior (EHUB), Kyoto University
- 2023/11/07 4:45pm
- Research Administration Building, Basement Floor (Conference Rooms 1&2) and Zoom
- English
- Onsite and Zoom
Summary
Appropriate animal models are needed to elucidate the pathogenesis of neuropsychiatric disorders, the causes of which are still poorly understood, and to develop new treatments. Several rodent models of neuropsychiatric disorders have been developed, including genetic modification, and drug-induced models. Our group aims to develop non-human primate models of these disorders to assess brain function and elucidate their pathology.
I am attempting to extract auditory hallucination activity from the brain using a developing model monkeys that causes neuro-inflammation in the neonatal period. This neuro-inflammatory model has been reported to show schizophrenia-like symptoms, EEG changes and neuronal activity changes in rodents. The common marmoset,a small primate native to South America, communicates between conspecifics using a variety of vocalizations. We found some abnormal behaviors in disease-model marmosets, but there is still no evidence to conclude that they are ‘schizophrenia’. Therefore, my Hakubi Project aims to extract the brain activity involved in auditory hallucinations using the model and to clarify the brain mechanisms of auditory hallucination.In this seminar, I would like to present the preliminary results and my plans in the Hakubi Project.