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My specialty is biophysics, especially mechanical properties of cell membrane. Recent studies have revealed that various cells in living organisms possess mechanical properties suited to their specific functions, closely linked to fundamental biological processes such as cell differentiation, aging, and cancer progression. However, the regulatory mechanisms and causal relationships underlying these phenomena remain largely unknown. Thus, I have developed a novel technique called ELASTomics, which enables comprehensive and simultaneous measurement of cellular mechanical properties and gene expression at the single-cell level.

In my Hakubi project, I perform ELASTomics to integratively analyse age-related changes in cellular mechanics and gene expression at the single-cell level, with the aim of uncovering their causal relationships and molecular mechanisms. By elucidating the molecular basis of age-related perturbations in cellular mechanical homeostasis, which may be a key factor in various age-related diseases, I aim to contribute to medical applications such as pathological diagnosis, drug discovery and anti-aging strategies. In addition, my research aims to extend to broader biological phenomena, including cancer progression and stem cell regulation.