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Masayoshi was born in Hashimoto, Wakayama Prefecture. Biomolecules are nanometer-sized molecular machines, which collaborate well in conjunction with water molecules. Currently, Masayoshi is seeking to develop a new analytical method to modify molecular structures and functions by utilizing high-pressure techniques and performing microscopic analyses with extremely high resolutions. This system could enable scientists to control molecular machines without the use of any chemical materials other than water molecules within those cells. The goal is thus to elucidate the mechanism of how molecular machines perform biological functions in collaboration with water molecules.