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Hiroshi aspired to be a life scientist after learning mystery of life from biology class in his high school days. Now, he has great interests in physiological importance of the existence of hypoxic microenvironments in the human body and molecular mechanisms underlying cellular adaptive response to hypoxia. Because human need oxygen for survival, one may feel strange about the existence of hypoxic regions in the body. In the Hakubi Project, he aim at investigating the developmental and physiological importance of heterogeneous oxygen microenvironments and elucidating molecular mechanisms underlying how their disorder triggers diseases, such as neoplasmic cell transformation.